| # | Game | Selling |
| 1 | Minecraft | 238M Copies Sold |
| 2 | Grand Theft Auto V | 165M Copies Sold |
| 3 | EA Tetris | 100M Copies Sold |
| 4 | Wii Sports | 82.9M Copies Sold |
| 5 | PlayerUnknown’s Battlegrounds | 75M Copies Sold |
| 6 | Super Mario Bros. | 58M Copies Sold |
| 7 | Mario Kart 8 & Deluxe | 53.7M Copies Sold |
| 8 | Pokémon Red and Blue | 47.5M Copies Sold |
| 9 | Terraria | 44.5M Copies Sold |
| 10 | Red Dead Redemption 2 | 44M Copies Sold |
| 11 | Wii Fit & Wii Fit Plus | 43.8M Copies Sold |
| 12 | Nintendo Tetris | 43M Copies Sold |
| 13 | Pac-Man | 42M Copies Sold |
| 14 | The Witcher 3 | 40M Copies Sold |
| 15 | Animal Crossing: New Horizons | 38.6M Copies Sold |
| 16 | Mario Kart Wii | 37.3M Copies Sold |
| 17 | Wii Sports Resort | 33.1M Copies Sold |
| 18 | New Super Mario Bros. Nintendo DS | 30.8M Copies Sold |
| 19 | New Super Mario Bros. Wii | 30.3M Copies Sold |
| 20 | The Elder Scrolls V: Skyrim | 30M Copies Sold |
| 21 | Call of Duty: Modern Warfare | 30M Copies Sold |
| 22 | Diablo III & Reaper of Souls | 30M Copies Sold |
| 23 | Human: Fall Flat | 30M Copies Sold |
| 24 | Pokémon Gold Silver & Crystal | 29.4M Copies Sold |
| 25 | Duck Hunt | 28.3M Copies Sold |
| 26 | Wii Play | 28M Copies Sold |
| 27 | Grand Theft Auto: San Andreas | 27.5M Copies Sold |
| 28 | Super Mario World | 26.6M Copies Sold |
| 29 | Call of Duty: Modern Warfare 3 | 26.5M Copies Sold |
| 30 | Call of Duty: Black Ops | 26.2M Copies Sold |
| 31 | The Legend of Zelda: Breath of the Wild | 25.8M Copies Sold |
| 32 | Super Smash Bros. Ultimate | 25.7M Copies Sold |
| 33 | Pokémon Sun and Moon & Ultra Sun and Ultra Moon | 25.2M Copies Sold |
| 34 | Grand Theft Auto IV | 25M Copies Sold |
| 35 | Pokémon Diamond / Pearl / Platinum | 24.7M Copies Sold |
| 36 | Super Mario Bros. 3 | 24.4M Copies Sold |
| 37 | Call of Duty Black Ops 2 | 24.2M Copies Sold |
| 38 | Kinect Adventures | 24M Copies Sold |
| 39 | FIFA 18 | 24M Copies Sold |
| 40 | Sonic the Hedgehog | 23.9M Copies Sold |
| 41 | Nintendogs | 23.9M Copies Sold |
| 42 | Mario Kart DS | 23.6M Copies Sold |
| 43 | Red Dead Redemption | 23M Copies Sold |
| 44 | Super Mario 64 / DS | 22.9M Copies Sold |
| 45 | Call of Duty: Modern Warfare 2 | 22.7M Copies Sold |
| 46 | Pokémon Sword / Shield | 22.6M Copies Sold |
| 47 | Pokémon Ruby / Sapphire / Emerald | 22.5M Copies Sold |
| 48 | Borderlands 2 | 22M Copies Sold |
| 49 | Super Mario Odyssey | 21.9M Copies Sold |
| 50 | New Super Mario Bros. U / Deluxe / Luigi U | 20.3M Copies Sold |
